"Critical appraisal skills enable you to assess the trustworthiness, relevance and results of published papers so that you can decide if they are believable and useful."
Randomized Controlled Trials
ROB 2.0 Risk Of Bias Tool
There are 3 variations of the tool based on trial design. Choose the appropriate version.
1. Individually randomized, parallel group trials (traditional RCT)
2. Cluster randomized, parallel group trials (like traditional but randomized by groups)
3. Individual randomized, cross-over trials (randomization occurs to determine the order the patient receives both treatments)
CASP: Randomised Controlled Trial Appraisal Tool
Summary: Critical Appraisal Skills Program (CASP): RCT CAT is a methodological checklist which provides key criteria relevant to randomised controlled trials.
Authors: Public Health Resource Unit, NHS, England
Non-randomized Studies or Observational Studies:
ROBINS-I Risk of Bias for non-randomized (observational) studies or cohorts of Interventions
ROBINS-E Risk of Bias for non-randomized (observational) studies or cohorts of Exposures other than interventions, including environmental and occupational exposures
Newcastle-Ottawa scale (NOS) -most widely used for case control or cohort studies
IHE Case Series Studies Critical Appraisal Checklist
JBI Critical Appraisal Checklist for Case Series
JBI Critical Appraisal Checklist for Case Reports
The Methodological Index for Non-Randomized Studies (MINOR) is a tool for assessing non-randomized interventional studies http://cobe.paginas.ufsc.br/files/2014/10/MINORS.pdf
Agency for Healthcare Research and Quality (AHRQ) methodological checklist for cross-sectional/prevalence studies
AXIS-To assess the quality of cross-sectional/prevalence studies
The TREND Statement
Summary: The TREND (Transparent Reporting of Evaluations with Nonrandomized Designs) statement is a 22-item checklist specifically developed to guide standardized reporting of nonrandomized controlled trials.
The STROBE Statement
Strengthening the reporting of observational studies (cohort, case-control, and cross-sectional)
McMaster Critical Review Forms and Guidelines - Quantitative and Qualitative Studies
Mixed Methods Appraisal Tool (MMAT)-used for qualitative, quantitative, and/or mixed methods studies. Helpful for those working on a Mixed Methods Review.
MetaQat - Meta-Tool for appraising all types of public health evidence
Quantitative Research (Public Health Research)
EPHPP- Quality Assessment tool for Quantitative Studies
Systematic Review Centre for Laboratory Animal Experimentation (SYRCLE) risk of bias assessment tool for assessing animal studies
(invivo studies) Review the ARRIVE guidelines
Critical Appraisal of Studies using Animal Models
To evaluate the risk of bias and applicability of primary diagnostic accuracy studies.
CASP: Diagnostic Test Studies
Centre for Evidence Based Medicine (CEBM) Diagnosis Critical Appraisal Worksheet
ROBIS- A tool for assessing the risk of bias in systematic reviews.
Joanna Briggs Critical Appraisal for Systematic Reviews Checklist-
AMSTAR 2-A Measurement Tool to Assess (quality assessment) of Systematic Reviews
Health-Evidence Appraisal Tool for Reviews
AHRQ-Assessing the Risk of Bias in Systematic Reviews of Healthcare Interventions
General Worksheets for Critical Appraisal of a variety of study designs:
Systematic Review Service:
The health sciences library Chat with a Librarian service is available at https://www.library.temple.edu/hsl. Many of our librarians are available to provide systematic review education. Or you may reach the Team Lead, Stephanie Roth: Email email@example.com Phone (215) 707-9469